Regulation of hydroxymethylglutaryl-CoA reductase in rat leukocytes
نویسندگان
چکیده
منابع مشابه
Regulation of hydroxymethylglutaryl-CoA reductase in rat leukocytes.
Methods were developed for the assay of hydroxymethylglutaryl-CoA reductase (NADPH) activity in microsomes from rat leukocytes. The activity in freshly isolated leukocytes is low compared to rat liver but can be assayed reliably. The patterns of response of leukocyte reductase in the assay to variation in substrate concentration, protein concentration, and time mimic those of rat liver reductas...
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initially high but declined as HMG-CoA reductase became activated. Glucagon prevented the loss of activity, whereas insulin promoted inactivation of the enzyme. Similar affects on the activity of HMG-CoA reductase kinase. and the state of phosphorylation of HMG-CoA reductase in liver have been reported after injection of rats with glucagon (Beg el al., 1979). Thus insulin and glucagon have conc...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1977
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)41599-8